含修饰D-苯丙氨酸残基的不对称短杆菌肽S类似物的合成与生物学评价

Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.

作者信息

van der Knaap Matthijs, Engels Eefje, Busscher Henk J, Otero José M, Llamas-Saiz Antonio L, van Raaij Mark J, Mars-Groenendijk Roos H, Noort Daan, van der Marel Gijsbert A, Overkleeft Herman S, Overhand Mark

机构信息

Bio-Organic Synthesis, Leiden Institute of Chemistry, University of Leiden, Leiden, The Netherlands.

出版信息

Bioorg Med Chem. 2009 Sep 1;17(17):6318-28. doi: 10.1016/j.bmc.2009.07.042. Epub 2009 Jul 25.

DOI:10.1016/j.bmc.2009.07.042

PMID:19674904

Abstract

The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several gram positive and negative strains, as well as their hemolytic activity is reported.

摘要

报道了具有修饰的D-苯丙氨酸残基的阳离子抗菌肽短杆菌肽S新类似物的合成、它们对几种革兰氏阳性和阴性菌株的抗菌特性以及它们的溶血活性。