原发性进行性失语（PPA）的临床病程及生物学特征
Clinical trajectories and biological features of primary progressive aphasia (PPA).
作者信息
Rogalski E J, Mesulam M M
机构信息
Cognitive Neurology and Alzheimers Disease Center, Northwestern University Feinberg School of Medicine, 320 E. Superior Street, Searle 11-579, Chicago, IL 60611, USA.
出版信息
Curr Alzheimer Res. 2009 Aug;6(4):331-6. doi: 10.2174/156720509788929264.
Abstract
Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome characterized by a gradual dissolution of language, but relative sparing of other cognitive domains during the initial stages of the disease. Research has led to substantial progress in understanding the clinical characteristics, genetics, and neuropathology of this syndrome. This article reviews the clinical criteria for diagnosing PPA, discusses the utility of defining the mild cognitive impairment (MCI) stage of PPA, and highlights some of the more recent research advances particularly in the area of pathology and genetics.
摘要
原发性进行性失语（PPA）是一种神经退行性综合征，其特征是语言功能逐渐衰退，但在疾病初期其他认知领域相对保留。研究在理解该综合征的临床特征、遗传学和神经病理学方面取得了重大进展。本文回顾了诊断PPA的临床标准，讨论了定义PPA轻度认知障碍（MCI）阶段的实用性，并重点介绍了一些最新的研究进展，特别是在病理学和遗传学领域。
相似文献
1
Clinical trajectories and biological features of primary progressive aphasia (PPA).
Curr Alzheimer Res. 2009 Aug;6(4):331-6. doi: 10.2174/156720509788929264.
2
An update on primary progressive aphasia.
Curr Neurol Neurosci Rep. 2007 Sep;7(5):388-92. doi: 10.1007/s11910-007-0060-0.
3
Dysexecutive Symptoms in Primary Progressive Aphasia: Beyond Diagnostic Criteria.
J Geriatr Psychiatry Neurol. 2017 May;30(3):151-161. doi: 10.1177/0891988717700507. Epub 2017 Mar 30.
4
[Primary progressive aphasia: clinical aspects].
Psychol Neuropsychiatr Vieil. 2006 Sep;4(3):189-200.
5
Early and Mild Phases of Primary Progressive Aphasia: A Case Series.
Curr Aging Sci. 2017;10(2):136-142. doi: 10.2174/1874609809666161024165937.
6
Longitudinal changes in brains of patients with fluent primary progressive aphasia.
Brain Lang. 2014 Apr;131:11-9. doi: 10.1016/j.bandl.2013.05.012. Epub 2013 Jun 21.
7
Progression of language decline and cortical atrophy in subtypes of primary progressive aphasia.
Neurology. 2011 May 24;76(21):1804-10. doi: 10.1212/WNL.0b013e31821ccd3c.
8
Primary progressive aphasia and the evolving neurology of the language network.
Nat Rev Neurol. 2014 Oct;10(10):554-69. doi: 10.1038/nrneurol.2014.159. Epub 2014 Sep 2.
9
[Aphasia and dementia].
Psychiatr Prax. 2001 Jul;28(5):246-8. doi: 10.1055/s-2001-15572.
10
Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia.
Neurology. 2017 Jun 13;88(24):2276-2284. doi: 10.1212/WNL.0000000000004034. Epub 2017 May 17.
引用本文的文献
1
Efficacy of Transcranial Magnetic Stimulation and Transcranial Direct-Current Stimulation in Primary Progressive Aphasia Treatment: A Review.
Brain Sci. 2025 Aug 5;15(8):839. doi: 10.3390/brainsci15080839.
2
Understanding Indirect Speech in Frontotemporal Dementia and Alzheimer's Disease Dementia: Validation of the Hinting Task - Dutch Version (HT-NL).
J Int Neuropsychol Soc. 2025 Aug 7:1-8. doi: 10.1017/S1355617725101197.
3
Efficacy of Communication Bridge-2 for primary progressive aphasia: A randomized controlled trial of communication intervention.
Alzheimers Dement. 2025 Mar;21(3):e70088. doi: 10.1002/alz.70088.
4
The use of low-density EEG for the classification of PPA and MCI.
Front Hum Neurosci. 2025 Feb 7;19:1526554. doi: 10.3389/fnhum.2025.1526554. eCollection 2025.
5
Atypical Presentations of Alzheimer Disease.
Continuum (Minneap Minn). 2024 Dec 1;30(6):1614-1641. doi: 10.1212/CON.0000000000001504.
6
Communication Bridge-2 randomized controlled trial: Recruitment and baseline features.
Alzheimers Dement. 2025 Jan;21(1):e14168. doi: 10.1002/alz.14168. Epub 2024 Nov 26.
7
Symptom-based staging for logopenic variant primary progressive aphasia.
Eur J Neurol. 2024 Jul;31(7):e16304. doi: 10.1111/ene.16304. Epub 2024 Apr 26.
8
Progression to corticobasal syndrome: a longitudinal study of patients with nonfluent primary progressive aphasia and primary progressive apraxia of speech.
J Neurol. 2024 Jul;271(7):4168-4179. doi: 10.1007/s00415-024-12344-x. Epub 2024 Apr 7.
9
Diagnostic performance of molecular imaging methods in predicting the progression from mild cognitive impairment to dementia: an updated systematic review.
Eur J Nucl Med Mol Imaging. 2024 Jun;51(7):1876-1890. doi: 10.1007/s00259-024-06631-y. Epub 2024 Feb 15.
10
Computer-Based Naming Treatment for Semantic Variant Primary Progressive Aphasia With History of Traumatic Brain Injury: A Single-Case Experimental Design.
J Speech Lang Hear Res. 2024 Feb 12;67(2):524-544. doi: 10.1044/2023_JSLHR-23-00289. Epub 2024 Feb 6.
本文引用的文献
1
Organizing a Series of Education and Support Conferences for Caregivers of Individuals With Frontotemporal Dementia and Primary Progressive Aphasia.
Alzheimers Care Q. 2006 Oct 1;7(4):243-250.
2
The logopenic/phonological variant of primary progressive aphasia.
Neurology. 2008 Oct 14;71(16):1227-34. doi: 10.1212/01.wnl.0000320506.79811.da. Epub 2008 Jul 16.
3
Covert processing of words and pictures in nonsemantic variants of primary progressive aphasia.
Alzheimer Dis Assoc Disord. 2008 Oct-Dec;22(4):343-51. doi: 10.1097/WAD.0b013e31816c92f7.
4
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia.
Ann Neurol. 2008 Jun;63(6):709-19. doi: 10.1002/ana.21388.
5
Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives.
Arch Neurol. 2008 Feb;65(2):244-8. doi: 10.1001/archneurol.2007.34.
6
Depression in Primary Progressive Aphasia.
J Geriatr Psychiatry Neurol. 2007 Sep;20(3):153-60. doi: 10.1177/0891988707303603.
7
Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration.
Acta Neuropathol. 2007 Jul;114(1):5-22. doi: 10.1007/s00401-007-0237-2. Epub 2007 Jun 20.
8
Primary progressive aphasia: relationship between gender and severity of language impairment.
Cogn Behav Neurol. 2007 Mar;20(1):38-43. doi: 10.1097/WNN.0b013e31802e3bae.
9
Profiles of decline in activities of daily living in non-Alzheimer dementia.
Alzheimer Dis Assoc Disord. 2007 Jan-Mar;21(1):8-13. doi: 10.1097/WAD.0b013e3180324549.
10
Altered effective connectivity within the language network in primary progressive aphasia.
J Neurosci. 2007 Feb 7;27(6):1334-45. doi: 10.1523/JNEUROSCI.4127-06.2007.
Zotero 插件