分工：GPCR亚基在受体二聚体中的不对称作用
A division of labor: asymmetric roles for GPCR subunits in receptor dimers.
作者信息
Zylbergold Peter, Hébert Terence E
机构信息
Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.
出版信息
Nat Chem Biol. 2009 Sep;5(9):608-9. doi: 10.1038/nchembio0909-608.
PMID:19690532
Abstract
The functional architecture of dimeric or oligomeric GPCR signaling remains incompletely understood. Using a clever combination of receptor-G protein fusions and various receptor mutations, new research provides a glimpse into how oligomers might be arranged with respect to the G proteins they interact with.
摘要
二聚体或寡聚体G蛋白偶联受体（GPCR）信号传导的功能架构仍未完全被理解。通过巧妙地结合受体 - G蛋白融合以及各种受体突变，新的研究让我们得以一窥寡聚体可能如何相对于它们所相互作用的G蛋白进行排列。
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