卡托普利和巯嘌呤：谁的 SH 具有更高的抗氧化能力？

Captopril and 6-mercaptopurine: whose SH possesses higher antioxidant ability?

机构信息

Department of Organic Chemistry, College of Chemistry, Jilin University, No. 2519 Jiefang Road, Changchun 130021, China.

出版信息

Eur J Med Chem. 2009 Dec;44(12):4841-7. doi: 10.1016/j.ejmech.2009.07.020. Epub 2009 Jul 30.

DOI:10.1016/j.ejmech.2009.07.020

PMID:19692149

Abstract

Antioxidant capacities of captopril (CAP), 6-mercaptopurine (6-MP) and 9-(beta-D-ribofuranosyl)-6-mercaptopurine (6-MPR) were investigated by interacting them with 2,2'-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical, and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cation radical (ABTS(+)()), and by protecting DNA and erythrocyte against 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) induced oxidation. It was found that CAP possessed the highest ability to donate the hydrogen atom in -SH to DPPH and galvinoxyl, while 6-MPR had the strongest ability to reduce ABTS(+)(). In the process of protecting DNA and erythrocytes against AAPH-induced oxidation, CAP can trap 0.5 and 1.3 radicals, 6-MP can trap 0.6 and 2.2, and 6-MPR can trap 1.0 and 3.0 radicals, respectively. CAP can also protect erythrocytes against hemin-induced hemolysis.

摘要

采用 2，2′-二苯基-1-苦肼基（DPPH）、戊二醛基自由基和 2，2′-连氮-双（3-乙基苯并噻唑啉-6-磺酸）阳离子自由基（ABTS（+）（））与卡托普利（CAP）、6-巯基嘌呤（6-MP）和 9-（β-D-核糖呋喃基）-6-巯基嘌呤（6-MPR）相互作用，研究了它们的抗氧化能力，并考察了它们对 2，2′-偶氮-二（2-脒基丙烷）盐酸盐（AAPH）诱导氧化条件下 DNA 和红细胞的保护作用。结果表明，CAP 具有向 DPPH 和戊二醛基提供 -SH 中氢原子的最高能力，而 6-MPR 具有最强的还原 ABTS（+）（）的能力。在保护 DNA 和红细胞免受 AAPH 诱导的氧化过程中，CAP 可以分别捕获 0.5 和 1.3 个自由基，6-MP 可以捕获 0.6 和 2.2 个自由基，6-MPR 可以捕获 1.0 和 3.0 个自由基。CAP 还可以保护红细胞免受血红素诱导的溶血。