Güngörmüş Metin, Akyol Utkan
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Ataturk University, Erzurum, Turkey.
Photomed Laser Surg. 2009 Dec;27(6):895-9. doi: 10.1089/pho.2008.2431.
To investigate the effect of low-level laser therapy (LLLT) on healing of skin incisions made using a diode laser in rats.
Eighteen Wistar rats were used for this study. Two parallel incisions (approximately 15 mm in length) were performed on the left and right side of the dorsum of each rat using a diode laser (4-W output powers with a tip 300 microm in diameter, 6 mm long, and 635-nm aiming beam). The wound on the left side of each rat received laser stimulation (10 J/cm2) from an 808-nm-wavelength gallium-aluminum-arsenide laser (Laser Source Power 20W, Laser Class IV, Medical Class IIB, Input Power Supply 230+/-10% VAC). They were assigned to two experimental groups: Group 1, diode laser (control); Group 2, diode laser+LLLT.
It was determined that there was a significant difference between the diode laser and diode laser+LLLT groups in inflammation at day 10 and a difference in reepithelization at day 20 but no significant difference in inflammation at day 20.
Diode laser incision (4 W) with 10 J/cm2 LLLT seems to have a beneficial effect on skin incisions in rats. As a result, it can be concluded that wound closure was significantly enhanced with lllt on diode laser incisions in rats.
研究低强度激光疗法(LLLT)对大鼠使用二极管激光进行皮肤切口愈合的影响。
本研究使用了18只Wistar大鼠。在每只大鼠背部的左侧和右侧使用二极管激光(输出功率4W,尖端直径300微米,长6毫米,瞄准光束波长635纳米)进行两条平行切口(长度约15毫米)。每只大鼠左侧的伤口接受来自波长808纳米的砷化镓铝激光(激光源功率20W,激光IV类,医用IIB类,输入电源230±10%VAC)的激光刺激(10J/cm²)。它们被分为两个实验组:第1组,二极管激光(对照组);第2组,二极管激光+LLLT。
确定在第10天时二极管激光组和二极管激光+LLLT组在炎症方面存在显著差异,在第20天时上皮再生存在差异,但在第20天时炎症方面无显著差异。
二极管激光切口(4W)联合10J/cm²的LLLT似乎对大鼠的皮肤切口有有益影响。因此,可以得出结论,LLLT可显著促进大鼠二极管激光切口的伤口闭合。