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特定基因低甲基化与癌症:编码区特征趋势的新见解

Specific gene hypomethylation and cancer: new insights into coding region feature trends.

作者信息

Daura-Oller Elias, Cabre Maria, Montero Miguel A, Paternain Jose L, Romeu Antoni

机构信息

Biochemistry and Biotechnology Department, Faculty of Chemistry, Rovira i Virgili, University (URV), c/ Marcel.li Domingo, s/n. Campus Sescelades, 43007 Tarragona, Spain.

出版信息

Bioinformation. 2009 Apr 21;3(8):340-3. doi: 10.6026/97320630003340.

Abstract

Giving coding region structural features a role in the hypomethylation of specific genes, the occurrence of G+C content, CpG islands, repeat and retrotransposable elements in demethylated genes related to cancer has been evaluated. A comparative analysis among different cancer types has also been performed. In this work, the inter-cancer coding region features comparative analysis carried out, show insights into what structural trends/patterns are present in the studied cancers.

摘要

鉴于编码区结构特征在特定基因低甲基化中所起的作用,已对与癌症相关的去甲基化基因中G+C含量、CpG岛、重复序列和逆转座子元件的出现情况进行了评估。还对不同癌症类型进行了比较分析。在这项工作中,所进行的癌症间编码区特征比较分析揭示了所研究癌症中存在哪些结构趋势/模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e092/2720671/71970e57e285/97320630003340F1.jpg

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