供体研究中导致移植物失败的供体风险因素。
Donor risk factors for graft failure in the cornea donor study.
机构信息
University of Illinois at Chicago, Chicago, IL, USA.
出版信息
Cornea. 2009 Oct;28(9):981-5. doi: 10.1097/ICO.0b013e3181a0a3e6.
PURPOSE
The purpose of this study was to assess the relationship between donor factors and 5-year corneal graft survival in the Cornea Donor Study.
METHODS
Donor corneas met criteria established by the Eye Bank Association of America, had an endothelial cell density of 2300 to 3300/mm, and were determined to be of good to excellent quality by the eye banks. Donor corneas were assigned using a random approach and surgeons were masked to information about the donor cornea including donor age. Surgery and postoperative care were performed according to the surgeons' usual routines and subjects were followed for 5 years. Donor and donor cornea factors were evaluated for their association with graft failure, which was defined as a regraft or a cloudy cornea that was sufficiently opaque to compromise vision for a minimum of 3 consecutive months.
RESULTS
Graft failure was not significantly associated with the type of tissue retrieval (enucleation versus in situ), processing factors, timing of use of the cornea, or characteristics of the donor or the donor cornea. Adjusting for donor age did not affect the results.
CONCLUSION
Donor and donor cornea characteristics do not impact graft survival rates for corneas comparable in quality to those used in this study.
目的
本研究旨在评估供体因素与角膜供体研究中 5 年角膜移植物存活率之间的关系。
方法
供体角膜符合美国眼库协会制定的标准，内皮细胞密度为 2300 至 3300 个/mm，并且由眼库确定为质量良好至优秀。供体角膜采用随机方法分配，并且外科医生对供体角膜的信息（包括供体年龄）进行了屏蔽。手术和术后护理按照外科医生的常规进行，并且对患者进行了 5 年的随访。评估了供体和供体角膜的因素与其移植物失败的相关性，移植物失败定义为再次移植或角膜混浊，其混浊程度足以使视力连续至少 3 个月受损。
结果
移植物失败与组织采集方式（眼球摘除术与原位）、处理因素、角膜使用时间、供体或供体角膜的特征之间没有显著相关性。调整供体年龄也不会影响结果。
结论
与本研究中使用的质量相当的角膜相比，供体和供体角膜的特征不会影响角膜移植物的存活率。
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