一名患有γ-干扰素自身抗体的患者出现复发性、多灶性鸟分枝杆菌-胞内分枝杆菌感染。
Recurrent, multifocal Mycobacterium avium-intercellulare infection in a patient with interferon-gamma autoantibody.
作者信息
Baerlecken N, Jacobs R, Stoll M, Schmidt R E, Witte T
机构信息
Clinic for Immunology and Rheumatology, Medical School of Hanover, Carl-Neuberg-Str 1, 30625 Hanover, Germany.
出版信息
Clin Infect Dis. 2009 Oct 1;49(7):e76-8. doi: 10.1086/605581.
DOI:10.1086/605581
PMID:19725781
Abstract
We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against interferon-gamma. In addition to antimycobacterial chemotherapy, we treated our patient with plasmapheresis and cyclophosphamide. The treatment induced a remission after 3 years of follow-up.
摘要
我们描述了一名因鸟分枝杆菌胞内感染和高滴度抗干扰素-γ自身抗体而发生严重骨髓炎的患者。除抗分枝杆菌化疗外，我们还对该患者进行了血浆置换和环磷酰胺治疗。经过3年的随访，治疗诱导病情缓解。
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