与年龄相关的 ENOX 蛋白（arNOX）活性与老年人的皮肤氧化损伤相关。

Age-related ENOX protein (arNOX) activity correlated with oxidative skin damage in the elderly.

机构信息

Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-2059, USA.

出版信息

Biofactors. 2008;34(3):237-44. doi: 10.3233/BIO-2009-1077.

DOI:10.3233/BIO-2009-1077

PMID:19734125

Abstract

ENOX proteins with an oscillatory pattern of production of superoxide (measured by ferricytochrome c reduction) and with a period length of 26 min increase linearity with age beginning at about 30 y to a maximum of about age 60. The proteins are shed and appear in serum, saliva and urine. Enhanced arNOX activity correlates with age and with oxidative changes contributing to skin aging. Topical cosmetic preparations containing substances that block arNOX activity are under evaluation to reduce visible symptoms of skin aging.

摘要

具有超氧化物（通过铁细胞色素 c 还原测定）产生的振荡模式的 ENOX 蛋白，其周期长度为 26 分钟，从大约 30 岁开始随着年龄的增长呈线性增加，最高可达大约 60 岁。这些蛋白质会脱落并出现在血清、唾液和尿液中。增强的 arNOX 活性与年龄相关，并与导致皮肤衰老的氧化变化有关。含有阻断 arNOX 活性的物质的局部美容制剂正在评估中，以减少皮肤衰老的可见症状。