莫西沙星对两名瘤型麻风患者体内麻风杆菌的快速杀灭作用。
Rapid killing of M. leprae by moxifloxacin in two patients with lepromatous leprosy.
作者信息
Pardillo Fe Eleanor F, Burgos Jasmin, Fajardo Tranquilino T, Dela Crux Eduardo, Abalos Rodolfo M, Paredes Rose Maria D, Andaya Cora Evelyn S, Gelber Robert H
机构信息
Leonard Wood Memorial Center for Leprosy Research, Cebu, Philippines.
出版信息
Lepr Rev. 2009 Jun;80(2):205-9.
INTRODUCTION
Previously we reported a 2-month clinical trial of moxifloxacin therapy in eight patients with MB leprosy (7 LL and 1 BL), finding both rapid killing of M. leprae and clinical improvement, without serious side effects or toxicities. Here we report the outcomes in two patients treated with moxifloxacin.
DESIGN
Two previously untreated LL patients were treated with a single 400 mg dose of moxifloxacin, no therapy for 7 days and then daily 400 mg moxifloxacin for 48 days. Clinical response, viability of M. leprae in the skin, and side effects/toxicities were carefully monitored.
RESULTS
In both patients a single dose of moxifloxacin resulted in significant killing of M. leprae (P < 0.001%). In both patients no viable M. leprae were found after 15 doses of moxifloxacin. Improvement in skin lesions occurred again remarkably rapidly and no untoward effects were noted.
CONCLUSION
Loss of viable M. leprae was quite rapid, similar to that found previously only for rifampicin, patients improved rapidly, and moxifloxacin was well tolerated.
引言
此前我们报告了一项针对8例多菌型麻风患者（7例瘤型和1例界线类偏瘤型）的莫西沙星治疗为期2个月的临床试验，发现其对麻风杆菌有快速杀菌作用且临床症状改善，无严重副作用或毒性。在此我们报告2例接受莫西沙星治疗患者的结果。
设计
2例既往未治疗的瘤型患者接受单次400mg剂量的莫西沙星治疗，7天不进行治疗，然后每日400mg莫西沙星治疗48天。仔细监测临床反应、皮肤中麻风杆菌的活力以及副作用/毒性。
结果
2例患者单次剂量的莫西沙星均导致麻风杆菌大量被杀灭（P<0.001%）。2例患者在接受15剂莫西沙星治疗后均未发现存活的麻风杆菌。皮肤损害再次显著快速改善，且未观察到不良影响。
结论
存活的麻风杆菌消失非常迅速，类似于之前仅在利福平治疗中发现的情况，患者改善迅速，且莫西沙星耐受性良好。
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