通过化学酶法获得多功能环氧喹诺合成子。

Chemoenzymatic access to versatile epoxyquinol synthons.

作者信息

Pinkerton David M, Banwell Martin G, Willis Anthony C

机构信息

Research School of Chemistry, Institute of Advanced Studies, The Australian National University, Canberra, ACT 0200, Australia.

出版信息

Org Lett. 2009 Oct 1;11(19):4290-3. doi: 10.1021/ol9016657.

DOI:10.1021/ol9016657

PMID:19743818

Abstract

The enantiomerically pure and readily available metabolites 10-12 have been converted over four simple steps into the epoxyquinol derivatives 22-24, respectively. Compounds 23 and 24 or their immediate precursors have been exploited in efficient total syntheses of (-)-bromoxone (ent-1), (-)-epiepoformin (ent-2), (-)-harveynone (4), (+)-panepophenanthrin (6), and (+)-hexacyclinol (9).

摘要

对映体纯且易于获得的代谢物10 - 12已分别通过四个简单步骤转化为环氧喹诺衍生物22 - 24。化合物23和24或其直接前体已被用于高效全合成（-）-溴氧酮（对映体-1）、（-）-表环氧福明（对映体-2）、（-）-哈维诺酮（4）、（+）-泛表菲环素（6）和（+）-六环醇（9）。