神经肽家族：进化视角

Neuropeptide families: an evolutionary perspective.

作者信息

Sherwood N M, Parker D B

机构信息

Department of Biology, University of Victoria, British Columbia, Canada.

出版信息

J Exp Zool Suppl. 1990;4:63-71. doi: 10.1002/jez.1402560412.

DOI:10.1002/jez.1402560412

PMID:1974805

Abstract

Changes in the structure and function of five neuropeptide families during evolution are considered. The families of gonadotropin-releasing hormone (GnRH), corticotropin-releasing factor (CRF), growth hormone-releasing hormone (GH-RH), somatostatin (SS), and vasopressin/oxytocin (VP/Oxy) are used as models to illustrate the importance of a phylogenetic approach in understanding neuropeptide structure/activity relationships, precursors, processing, gene duplication, novel locations and functions, and gene-associated peptides.

摘要

本文探讨了五个神经肽家族在进化过程中的结构和功能变化。以促性腺激素释放激素（GnRH）、促肾上腺皮质激素释放因子（CRF）、生长激素释放激素（GH-RH）、生长抑素（SS）以及血管加压素/催产素（VP/Oxy）家族作为模型，来说明系统发育方法在理解神经肽结构/活性关系、前体、加工、基因复制、新的定位和功能以及基因相关肽方面的重要性。