光动力疗法增强抗肿瘤免疫。
Enhancement of anti-tumor immunity by photodynamic therapy.
机构信息
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
出版信息
Immunol Res. 2010 Mar;46(1-3):216-26. doi: 10.1007/s12026-009-8119-4.
Abstract
Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumors, resulting in cure of early disease and palliation of advanced disease. PDT was originally considered to be a local treatment; however, both pre-clinical and clinical studies have shown that local PDT treatment of tumors can enhance systemic anti-tumor immunity. The current state of investigations into the ability of PDT to enhance anti-tumor immunity, the mechanisms behind this enhancement and the future of PDT as an immunotherapy are addressed in this review.
摘要
光动力疗法（PDT）是一种获得 FDA 批准的治疗方法，可迅速消除局部肿瘤，从而根治早期疾病并缓解晚期疾病。PDT 最初被认为是一种局部治疗方法；然而，临床前和临床研究都表明，局部 PDT 治疗肿瘤可以增强全身抗肿瘤免疫力。本文综述了 PDT 增强抗肿瘤免疫力的能力、增强作用背后的机制以及 PDT 作为免疫疗法的未来。
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