在杂交和回交群体中进行数量性状基因座定位。

QTL mapping in intercross and backcross populations.

作者信息

Zou Fei

机构信息

Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.

出版信息

Methods Mol Biol. 2009;573:157-73. doi: 10.1007/978-1-60761-247-6_9.

DOI:10.1007/978-1-60761-247-6_9

PMID:19763927

Abstract

In the past two decades, various statistical approaches have been developed to identify quantitative trait locus with experimental organisms. In this chapter, we introduce several commonly used QTL mapping methods for intercross and backcross populations. Important issues related to QTL mapping, such as threshold and confidence interval calculations are also discussed. We list and describe five public domain QTL software packages commonly used by biologists.

摘要

在过去二十年中，已经开发出各种统计方法来在实验生物体中鉴定数量性状基因座。在本章中，我们介绍几种常用于杂交和回交群体的QTL定位方法。还讨论了与QTL定位相关的重要问题，如阈值和置信区间的计算。我们列出并描述了生物学家常用的五个公共领域QTL软件包。