通过有机催化的羟醛反应不对称合成(-)-肠内酯和(7'R)-7'-羟基肠内酯。
Asymmetric syntheses of (-)-enterolactone and (7'R)-7'-hydroxyenterolactone via organocatalyzed aldol reaction.
作者信息
Hajra Saumen, Giri Aswini Kumar, Hazra Sunit
机构信息
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302, India.
出版信息
J Org Chem. 2009 Oct 16;74(20):7978-81. doi: 10.1021/jo900810a.
PMID:19775122
Abstract
Short syntheses of (-)-enterolactone (1a) and (7'R)-7'-hydroxyenterolactone (1b) have been achieved utilizing organocatalyzed asymmetric cross-aldol reaction of aldehydes 2 and 3 and base-mediated alkylation of lactones 5 and 4.
摘要
利用醛2和3的有机催化不对称交叉羟醛反应以及内酯5和4的碱介导烷基化反应，已实现了（-）-肠内酯（1a）和（7'R）-7'-羟基肠内酯（1b）的短合成。
Zotero 插件