脑动脉瘤的血流动力学
Hemodynamics of Cerebral Aneurysms.
作者信息
Sforza Daniel M, Putman Christopher M, Cebral Juan Raul
机构信息
Center for Computational Fluid Dynamics, George Mason University, Fairfax, Virginia 22030.
出版信息
Annu Rev Fluid Mech. 2009 Jan 1;41:91-107. doi: 10.1146/annurev.fluid.40.111406.102126.
Abstract
The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The combination of abnormal blood patterns and genetics predisposition could lead to the pathological formation of aneurysms. Here, we review recent progress on the basic mechanisms of aneurysm formation and evolution, with a focus on the role of hemodynamic patterns.
摘要
脑动脉瘤的发生和发展是由生物学和血流动力学因素复杂相互作用驱动的动脉壁退行性过程。动脉壁上的内皮细胞对血流模式产生生理反应。在正常情况下，这些反应与非病理性组织重塑和适应相关。异常血流模式与遗传易感性相结合可能导致动脉瘤的病理性形成。在此，我们综述了动脉瘤形成和演变基本机制的最新进展，重点关注血流动力学模式的作用。
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