Brazilian Obsessive-Compulsive Research Consortium, Brazil.
Psychiatry Res. 2009 Nov 30;170(1):32-42. doi: 10.1016/j.psychres.2008.06.008. Epub 2009 Oct 3.
The question of whether Tourette's syndrome (TS) and trichotillomania (TTM) are best conceptualized as obsessive-compulsive spectrum disorders was raised by family studies demonstrating a close relationship between TS and obsessive-compulsive disorder (OCD), and by psychopharmacological research indicating that both TTM and OCD respond more robustly to clomipramine than to desipramine. A range of studies have subsequently allowed comparison of the phenomenology, psychobiology, and management of TS and TTM, with that of OCD. Here we briefly review this literature. The data indicate that there is significant psychobiological overlap between TS and OCD, supporting the idea that TS can be conceptualized as an OCD spectrum disorder. TTM and OCD have only partial overlap in their phenomenology and psychobiology, but there are a number of reasons for why it may be useful to classify TTM and other habit disorders as part of the obsessive-compulsive spectrum of disorders.
抽动秽语综合征 (TS) 和拔毛癖 (TTM) 是否最好被视为强迫症谱系障碍，这一问题引起了关注，因为家族研究表明 TS 与强迫症 (OCD) 之间存在密切关系，而精神药理学研究表明，TTM 和 OCD 对氯米帕明的反应比去甲丙咪嗪更强烈。随后的一系列研究允许将 TS 和 TTM 的发病机制、精神生物学和治疗与 OCD 进行比较。在这里，我们简要回顾一下相关文献。这些数据表明，TS 和 OCD 之间存在显著的精神生物学重叠，支持了将 TS 概念化为 OCD 谱系障碍的观点。TTM 和 OCD 在发病机制和精神生物学方面只有部分重叠，但有许多原因可以将 TTM 和其他习惯障碍归类为强迫症谱系障碍的一部分。
