UMDNJ-New Jersey Medical School, Newark, NJ, USA.
Mult Scler. 2009 Nov;15(11):1271-9. doi: 10.1177/1352458509107017. Epub 2009 Oct 5.
There is increasing recognition of the important role that B cells play in the pathogenesis of multiple sclerosis (MS). Recently it was reported that the B cell chemokine CXCL13 is elevated in MS serum and cerebrospinal fluid. Here we study whether serum levels of CXCL13 are associated with active MS. We measured serum levels of CXCL13 by enzyme-linked immunosorbent assay in 74 patients with relapsing MS randomized to interferon beta 1b or glatiramer acetate and examined with monthly 3 T brain MRI scans optimized for detection of gadolinium-enhancement for up to 2 years. The median (range) serum levels of CXCL13 pre-treatment were 40 (3-171) pg/ml. Serum levels of CXCL13 were significantly higher at times of active brain MRI scans (p < 0.01). Furthermore, serum levels were higher in patients who never reached MRI remission compared with those in complete (p < 0.01) or partial (p = 0.01) remission. There was a significant positive correlation between the pattern of serum levels of CXCL13 and MRI activity during the first (r = 0.33, p < 0.05) and the full 2 years (r = 0.35, p < 0.01) of the study. Treatment with interferon beta 1b or glatiramer acetate did not affect serum CXCL13. We conclude that the serum levels of the B cell chemokine CXCL13 are associated with active MS.
人们越来越认识到 B 细胞在多发性硬化症（MS）发病机制中的重要作用。最近有报道称，B 细胞趋化因子 CXCL13 在 MS 血清和脑脊液中升高。在这里，我们研究了 CXCL13 的血清水平是否与活动期 MS 相关。我们通过酶联免疫吸附试验测量了 74 例复发型 MS 患者的血清 CXCL13 水平，这些患者随机分为干扰素β 1b 或醋酸格拉替雷组，并进行了长达 2 年的每月 3T 脑部 MRI 扫描，优化了钆增强的检测。预处理时 CXCL13 的血清中位数（范围）为 40（3-171）pg/ml。在活跃的脑部 MRI 扫描时，血清 CXCL13 水平显著升高（p < 0.01）。此外，与完全缓解（p < 0.01）或部分缓解（p = 0.01）患者相比，从未达到 MRI 缓解的患者血清 CXCL13 水平更高。在研究的第一年（r = 0.33，p < 0.05）和整个 2 年（r = 0.35，p < 0.01）期间，血清 CXCL13 水平与 MRI 活动之间存在显著的正相关。用干扰素β 1b 或醋酸格拉替雷治疗并不影响血清 CXCL13。我们的结论是，B 细胞趋化因子 CXCL13 的血清水平与活动期 MS 相关。
