一例Brugada综合征患者，其日间心电图变化与性激素的昼夜节律相关。
A case of Brugada syndrome in which diurnal ECG changes were associated with circadian rhythms of sex hormones.
作者信息
Yamaki Masaru, Sato Nobuyuki, Okada Motoi, Fujita Satoshi, Go Kazutomo, Sakamoto Naka, Tanabe Yasuko, Takeuchi Toshiharu, Kawamura Yuichiro, Hasebe Naoyuki
机构信息
Department of Emergency Medicine, Asahikawa Medical College, Hokkaido, Japan.
出版信息
Int Heart J. 2009 Sep;50(5):669-76. doi: 10.1536/ihj.50.669.
We describe a thought-provoking case of Brugada syndrome in which a relationship between the diurnal electrocardiogram (ECG) changes and sex hormone levels was observed. A 36-year-old man who experienced cardiac arrest was referred to our hospital. He had a family history of sudden cardiac death. The 12-lead ECG exhibited a mild coved type ST-segment elevation in leads V1 and V2, which was enhanced by intravenous pilsicainide injection. Hence, this case was diagnosed as Brugada syndrome. The circadian rhythm of the serum testosterone level revealed low levels in the daytime (1.66-1.99 ng/mL) and high levels (2.52-3.42 ng/mL) in the nighttime. Interestingly, augmentation of the ST segment elevation and widening of the P wave were observed at around 2:00 AM, when the serum testosterone was recorded at its highest. Our report discusses the influence of the circadian rhythms of sex hormones on the ECG changes in Brugada syndrome.
我们描述了一例发人深省的 Brugada 综合征病例，其中观察到了昼夜心电图（ECG）变化与性激素水平之间的关系。一名经历过心脏骤停的 36 岁男性被转诊至我院。他有心脏性猝死家族史。12 导联心电图显示 V1 和 V2 导联有轻度穹窿型 ST 段抬高，静脉注射吡西卡尼后抬高增强。因此，该病例被诊断为 Brugada 综合征。血清睾酮水平的昼夜节律显示白天水平较低（1.66 - 1.99 ng/mL），夜间水平较高（2.52 - 3.42 ng/mL）。有趣的是，在凌晨 2:00 左右，当血清睾酮记录为最高水平时，观察到 ST 段抬高增加和 P 波增宽。我们的报告讨论了性激素昼夜节律对 Brugada 综合征心电图变化的影响。
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