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[脐带血储存]

[Cord blood banking].

作者信息

Cepulić Branka Golubić, Bojanić Ines, Mazić Sanja

机构信息

Zavod za transfuziologiju, Klinicki bolnicki centar Zagreb, Zagreb, Hrvatska.

出版信息

Acta Med Croatica. 2009 Jun;63(3):245-50.

Abstract

Transplantation of cord blood stem cells is a new and rapidly developing area. It has been used as a treatment for many diseases such as hematologic malignancies, primary immune deficiencies and metabolic diseases. Recently, stem cells have been used in regenerative medicine, particularly in neurodegenerative and cardiovascular diseases. For these reasons interest has been growing in banking cord blood. To be able to find an acceptable donor for any recipient in need, it is necessary to have on stock a great diversity of cells with different genetic types from different populations. Networks of banks and registries have been created around the world in order to share and exchange transplants. Public banks organize collection for altruistic donor of cord blood for unrelated hematopoietic stem cell transplantation and for directed donation in families at risk. But there are increasing numbers of families that are requesting storage of cord blood for possible future therapeutic use in the family. Establishment of cord blood banks has raised a number of important scientific, legal, ethical and political issues, which are discussed in this paper.

摘要

脐带血干细胞移植是一个新兴且发展迅速的领域。它已被用于治疗多种疾病,如血液系统恶性肿瘤、原发性免疫缺陷病和代谢性疾病。最近,干细胞已被应用于再生医学,尤其是在神经退行性疾病和心血管疾病方面。基于这些原因,人们对储存脐带血的兴趣日益浓厚。为了能够为任何有需要的受者找到合适的供体,有必要储备来自不同人群、具有不同基因类型的大量细胞。世界各地已经建立了银行和登记处网络,以便共享和交换移植资源。公共银行组织采集脐带血,用于利他性脐带血供体的非亲缘造血干细胞移植以及为有风险家庭的定向捐赠。但越来越多的家庭要求储存脐带血,以备将来可能在家庭中用于治疗。脐带血库的建立引发了一些重要的科学、法律、伦理和政治问题,本文将对此进行讨论。

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