Sólyom F, Fazekas A, Czelleng F, Makár A, Roith J
Dev Biol Stand. 1976;35:113-5.
Various oil adjuvants were tested for immunogenicity enhancing action in "C" type FMD monovaccine preparations. The following composition proved to be optimal in mouse tests: Bayl F 85%, Arlacel A 14% Tween 80 1%. As to the quantitative relations of antigen adjuvant, 40% oil to 60% antigen was the best among all proportions tested. Oil-adjuvanted vaccines failed to evoke an immune response in calves, but proved to be the preparation of choice for adult cattle. Oil containing and DEAE-dextran-containing vaccines had an equal efficiency in pigs; both conferred full protection on one in three pigs treated with 2.5-fold bovine doses. The number of vaccinated pigs was too small to permit definitive conclusions, but it seems clear that only oil dextran are efficient adjuvants of FMD vaccines for pigs, and that the antigen component of such vaccines should be increased considerably in order to obtain a greater potency.
对各种油佐剂在“C”型口蹄疫单价疫苗制剂中的免疫原性增强作用进行了测试。以下配方在小鼠试验中被证明是最佳的：Bayl F 85%、阿拉赛A 14%、吐温80 1%。至于抗原佐剂的定量关系，在所有测试比例中，40%的油与60%的抗原是最佳组合。含油佐剂的疫苗未能在犊牛中引发免疫反应，但被证明是成年牛的首选制剂。含油和含DEAE-葡聚糖的疫苗在猪身上具有相同的效果；用2.5倍牛剂量处理的三头猪中，二者都能为其中一头提供完全保护。接种猪的数量太少，无法得出明确结论，但似乎很明显，只有油葡聚糖是猪口蹄疫疫苗的有效佐剂，并且为了获得更高的效力，此类疫苗的抗原成分应大幅增加。
