角鲨烯四环氧的立体和区域选择性合成。
Stereo- and regioselective synthesis of squalene tetraepoxide.
机构信息
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
出版信息
J Org Chem. 2009 Nov 6;74(21):8407-9. doi: 10.1021/jo901920d.
PMID:19827774
Abstract
Squalene tetraepoxide, a putative biosynthetic precursor to a variety of oxacyclic triterpenoid natural products, has been efficiently synthesized by anionic coupling of two farnesol-derived diepoxides, which have arisen from electronic control of the regioselectivity in organocatalytic enantioselective epoxidations.
摘要
角鲨烯四环氧物是一种假定的生物合成前体，可用于多种氧杂环三萜天然产物的合成，通过两种法呢醇衍生的双环氧物的阴离子偶联，高效合成了角鲨烯四环氧物，该双环氧物是通过有机催化对映选择性环氧化反应的区域选择性的电子控制而产生的。
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