Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
J Hypertens. 2010 Feb;28(2):245-50. doi: 10.1097/HJH.0b013e32833310e0.
The association between tobacco smoking and blood pressure in epidemiological studies remains unclear despite experimental evidence that smoking elevates blood pressure. This study examined the association between smoking and hypertension in a population-based sample of Vietnamese men.
The study utilized a population-based sample of men (n = 910) from a survey of risk factors of noncommunicable diseases in Vietnam. Measurements including behavioural risk factors, body composition, and blood pressure were performed according to internationally standardized protocols. Poisson regression was used to obtain prevalence ratios and 95% confidence intervals (CIs). All analyses were performed using complex survey methods.
There were significant trends of increasing prevalence of hypertension with increasing years (P = 0.05) and pack-years (P = 0.03) of smoking after adjusting for age, BMI, and alcohol intake. Relative to never-smokers, the risk of hypertension for those who had smoked for 30 years or more and those who had smoked 20 pack-years or more were 1.52 (95% CI 0.95-2.44) and 1.34 (95% CI 0.94-1.91), respectively. Overall, however, current smokers were not at higher risk of hypertension than never-smokers (prevalence ratio = 1.08, 95% CI 0.70-1.68), and ex-smokers were more likely to be hypertensive than either never-smokers (prevalence ratio = 1.81, 95% CI 1.07-3.06) or current smokers (prevalence ratio = 1.67, 95% CI 1.25-2.23), similarly adjusted.
In this population-based sample, hypertension was associated with smoking in a dose-response manner when characterized as number of years of smoking and lifetime cigarette consumption, but was not associated with current smoking status.
尽管有实验证据表明吸烟会升高血压,但在流行病学研究中,吸烟与血压之间的关联仍不清楚。本研究在越南男性的基于人群的样本中研究了吸烟与高血压之间的关系。
该研究利用了越南非传染性疾病危险因素调查的基于人群的男性样本(n=910)。根据国际标准化协议进行了包括行为危险因素、身体成分和血压在内的测量。使用泊松回归获得患病率比和 95%置信区间(CI)。所有分析均使用复杂的调查方法进行。
在校正年龄、BMI 和酒精摄入量后,随着吸烟年限(P=0.05)和吸烟包年数(P=0.03)的增加,高血压的患病率呈显著上升趋势。与从不吸烟者相比,吸烟 30 年或以上且吸烟 20 包年或以上者患高血压的风险分别为 1.52(95%CI 0.95-2.44)和 1.34(95%CI 0.94-1.91)。然而,总体而言,目前吸烟者患高血压的风险并不高于从不吸烟者(患病率比=1.08,95%CI 0.70-1.68),而戒烟者患高血压的可能性高于从不吸烟者(患病率比=1.81,95%CI 1.07-3.06)或目前吸烟者(患病率比=1.67,95%CI 1.25-2.23),同样进行了调整。
在本基于人群的样本中,吸烟与高血压之间呈剂量反应关系,其特征为吸烟年限和终生吸烟量,但与当前吸烟状况无关。