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[肺癌流行病学的新进展:非吸烟者、女性以及大麻的作用?]

[What is new in the epidemiology of lung cancer: non-smokers, women and the role of cannabis?].

作者信息

Quoix Elisabeth

机构信息

Service de pneumologie, CHU Strasbourg, 67091 Strasbourg Cedex.

出版信息

Rev Prat. 2009 Sep 20;59(7):920-4.

Abstract

Lung cancer is in France, like in other countries, the first cause of death by cancer in men. It has become the third one in women in a few years span. If smoking is the main cause of lung cancer, other causes have been quite neglected for years such as occupational risk mainly asbestos exposure. Lung cancer in non-smokers has increased during the last years. This may be a real increase or the consequence of ageing of the general population with increased incidence of lung cancer rather due to age than to tobacco. The considerable increase in women's incidence of lung cancer is partly due to the development of smoking habits since 1960 in France. The possibility of an increased suceptibility to tobacco smoke in women is biologically plausible but still very controversial. The role of cannabis smoke is also controversial since it is very difficult to isolate the effects of cannabis which is in the majority of cases smoked with tobacco. However, recent studies are in favor of an independent role of cannabis in the development of lung cancers.

摘要

在法国,肺癌如同在其他国家一样,是男性因癌症死亡的首要原因。在短短几年内,它已成为女性因癌症死亡的第三大原因。如果说吸烟是肺癌的主要病因,那么其他病因多年来一直被相当程度地忽视了,比如职业风险,主要是石棉暴露。在过去几年中,不吸烟者患肺癌的人数有所增加。这可能是实际的增长,也可能是由于总体人口老龄化导致肺癌发病率上升,更多是因为年龄而非烟草。法国女性肺癌发病率的显著上升部分归因于自1960年以来吸烟习惯的发展。女性对烟草烟雾易感性增加在生物学上看似合理,但仍极具争议。大麻烟雾的作用也存在争议,因为在大多数情况下,大麻是与烟草一起吸食的,很难分离出大麻的影响。然而,最近的研究支持大麻在肺癌发展中具有独立作用。

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