Mackenzie C D, Lazarus W M, Mwakitalu M E, Mwingira U, Malecela M N
Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA.
Ann Trop Med Parasitol. 2009 Oct;103 Suppl 1:S41-51. doi: 10.1179/000349809X12502035776630.
The defining images of lymphatic filariasis are the horrendous disfigurements of lymphoedema, elephantiasis and hydrocele. These clinical presentations, although obviously important and life changing, are not, however, the only outcomes of this wide-spread filarial infection. The other effects of the disease range from severe, acute but short-term bouts of sickness to psychological impairment, poverty and family hardship. It is important to support cases of the disease through all means available, such as reparative hydrocelectomy, hygiene training and facilitation, and the provision of adequate chemotherapy. Although only a minority of the residents in any endemic community is affected with the severe clinical manifestations of this parasitic infection, these cases are central to, and important advocates for, the current global effort to eliminate the infection through mass drug administrations (MDA). Their clinical improvement acts as an important catalyst for the general population and encourages high compliance in the MDA. This communication discusses the central role that filariasis patients have played in the Tanzania Lymphatic Filariasis Elimination Programme to date, and covers some of the clinical successes achieved in the past 10 years. The abolition of the clinical manifestations of filarial infection remains the ultimate goal of the Global Programme to Eliminate Lymphatic Filariasis, and maintaining a focus on the affected individuals and their clinical condition is vital to that programme's overall success.
淋巴丝虫病的典型症状是淋巴水肿、象皮肿和鞘膜积液造成的可怕畸形。这些临床表现虽然显然很重要且会改变人生,但并不是这种广泛传播的丝虫感染的唯一后果。该疾病的其他影响包括严重的急性但短期疾病发作、心理障碍、贫困和家庭困境。通过各种可用手段支持该疾病患者很重要,比如进行修复性鞘膜积液切除术、提供卫生培训与便利,以及提供足够的化疗。尽管在任何流行社区中只有少数居民受到这种寄生虫感染严重临床表现的影响,但这些病例对于当前通过大规模药物给药(MDA)消除感染的全球努力至关重要,也是重要的倡导者。他们的临床改善对普通人群起到了重要的催化作用,并鼓励人们在MDA中高度配合。本通讯讨论了丝虫病患者迄今在坦桑尼亚淋巴丝虫病消除计划中所发挥的核心作用,并介绍了过去10年取得的一些临床成功案例。消除丝虫感染的临床表现仍然是全球消除淋巴丝虫病计划的最终目标,关注受影响个体及其临床状况对于该计划的整体成功至关重要。