Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.
Curr Opin Cell Biol. 2009 Dec;21(6):878-84. doi: 10.1016/j.ceb.2009.09.005. Epub 2009 Oct 21.
The regulation of apoptosis (programmed cell death) has been the subject of a vast body of research because of its implications in normal development, tissue homeostasis and a wide range of diseases. The ubiquitin-proteasome system (UPS) plays a prominent role in the control of apoptosis by targeting key cell death proteins, including caspases, the central executioners of apoptosis. Here we summarize the major findings on the function of the UPS in both pro- and anti-apoptotic regulation.
细胞凋亡(程序性细胞死亡)的调控一直是大量研究的主题,因为它涉及到正常发育、组织平衡和多种疾病。泛素-蛋白酶体系统(UPS)通过靶向关键的细胞死亡蛋白,包括细胞凋亡的中心执行者 caspase,在细胞凋亡的控制中起着重要作用。在这里,我们总结了 UPS 在促进和抑制细胞凋亡调节中的主要功能发现。