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[英夫利昔单抗治疗银屑病期间的脾结核]

[Splenic tuberculosis during psoriasis treatment with infliximab].

作者信息

Fortaleza Gleyce Tavares de Melo, Brito Maria de Fátima de Medeiros, Santos Josemir Belo dos, Figueiredo Ana Roberta, Gomes Perla

机构信息

Hospital das Clínicas de Pernambuco, Universidade Federal de Pernambuco, Recife, PE, Brasil.

出版信息

An Bras Dermatol. 2009 Jul-Aug;84(4):420-4. doi: 10.1590/s0365-05962009000400016.

Abstract

Psoriasis is a chronic inflammatory disease affecting the skin and occasionally the joints. The biological agents have been engineered to target a specific step in the inflammatory cascade that leads to psoriasis, including tumor necrosis factor, which has a central role in the host defense against Mycobacterium tuberculosis. This is a case report about a psoriatic patient who presented splenic tuberculosis during treatment with infliximab.

摘要

银屑病是一种影响皮肤且偶尔累及关节的慢性炎症性疾病。生物制剂被设计用于靶向导致银屑病的炎症级联反应中的特定步骤,包括肿瘤坏死因子,其在宿主抵御结核分枝杆菌的防御中起核心作用。这是一篇关于一名银屑病患者在接受英夫利昔单抗治疗期间出现脾结核的病例报告。

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