Foxn1 对于鼠胸腺原基的血管生成至关重要。

Foxn1 is essential for vascularization of the murine thymus anlage.

机构信息

Department of Immunology and Microbiology, Meiji University of Integrative Medicine, Hiyoshi-cho, Nantan, Kyoto 629-0392, Japan.

出版信息

Cell Immunol. 2010;260(2):66-9. doi: 10.1016/j.cellimm.2009.09.007.

DOI:10.1016/j.cellimm.2009.09.007

PMID:19853842

Abstract

We addressed whether vascularization of the thymus anlage depends on Foxn1 expression. In the thymus anlagen of wild-type mice, CD31(+) endothelial cells are initially observed between epithelial cells on embryonic day (Ed)12.5 and form luminal structure on Ed13. VEGF are produced in epithelial cells and mesenchymal cells which invaginate in the epithelial region of the anlagen on Ed13. However, in the nude thymus anlagen, neither CD31(+) cells nor VEGF producing mesenchymal cells is detected in the epithelial region. The present results indicate that Foxn1 dependent epithelial development is essential for vascularization of the thymus anlagen.

摘要

我们研究了胸腺原基的血管生成是否依赖于 Foxn1 的表达。在野生型小鼠的胸腺原基中，CD31(+)内皮细胞最初在胚胎第 12.5 天（Ed）观察到在上皮细胞之间，并且在 Ed13 形成腔结构。VEGF 在侵入上皮区域的上皮细胞和间充质细胞中产生。然而，在裸鼠的胸腺原基中，上皮区域均未检测到 CD31(+)细胞或产生 VEGF 的间充质细胞。本研究结果表明，Foxn1 依赖性上皮发育对于胸腺原基的血管生成是必需的。