Department of Pathology, Cornell University Medical College, and the Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1929 Aug 31;50(3):341-53. doi: 10.1084/jem.50.3.341.
Rabbits bearing very intensive skin lesions resulting from the intracutaneous injection of neurovirus plus testicular extract show typical histological alterations in the gonads, suprarenals, liver, spleen, lung, lymph nodes, and bone marrow. Similar but less wide-spread alterations are found after intravenous injection of neurovirus. Although testicle extract injected intracutaneously with neurovirus has a marked enhancing action upon the activity of the latter, the same mixture injected intravenously yields no sign of any such enhancement. The significance of these observations as regards the question of the ectodermotropism of vaccine virus is discussed, and the doctrine of specific organ affinities is considered.
经皮内注射神经病毒加睾丸提取物后,兔子出现严重的皮肤损伤,其生殖腺、肾上腺、肝脏、脾脏、肺、淋巴结和骨髓出现典型的组织学改变。静脉内注射神经病毒后,也会出现类似但范围较小的改变。虽然用神经病毒皮内注射睾丸提取物对后者的活性有显著增强作用,但同样的混合物静脉内注射则没有任何增强作用的迹象。这些观察结果对于疫苗病毒的外胚层趋向性问题具有重要意义,并对特异性器官亲和力学说进行了讨论。