胆红素在小肠中的命运。
FATE OF BILIRUBIN IN THE SMALL INTESTINE.
机构信息
Laboratory of Research Surgery, University of Pennsylvania, Philadelphia.
出版信息
J Exp Med. 1934 Jul 31;60(2):189-98. doi: 10.1084/jem.60.2.189.
Since there was no loss of bilirubin from the jejunal loop, and no loss of bilirubin when pigment was incubated with juice from the loop segment, or juice from the entire small intestine, it may be concluded that the intestinal juice per se has no effect in converting bilirubin to urobilin in a 2 hour period, and that in the jejunal loop there was no absorption of pigment or no conversion to urobilin. The experiments showing loss of pigment in the entire intestinal tract suggest that in some place other than the jejunal portion of the intestine the combined activity of intestinal contents and intestinal cells does affect the bilirubin in the intestine. Whether the loss of bile pigment under such circumstances is due entirely to conversion, or to conversion and absorption, or to absorption of bilirubin as such, remains to be answered by subsequent investigations.
由于从小肠袢中没有胆红素丢失，而且当色素与回肠段的肠液或整个小肠的肠液孵育时也没有胆红素丢失，因此可以得出结论，在 2 小时内肠液本身不会使胆红素转化为尿胆素，而且在空肠袢中没有色素吸收，也没有转化为尿胆素。表明整个肠道中色素丢失的实验表明，除空肠部分外，肠内容物和肠细胞的联合活性确实会影响肠道中的胆红素。在这种情况下，胆色素的丢失是否完全归因于转化，或者归因于转化和吸收，或者归因于胆红素本身的吸收，仍有待后续研究回答。
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