在自然条件下从野兔乳头瘤病毒衍生而来的癌症。
CANCERS DERIVING FROM THE VIRUS PAPILLOMAS OF WILD RABBITS UNDER NATURAL CONDITIONS.
机构信息
Laboratories of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1940 Mar 31;71(4):469-94. doi: 10.1084/jem.71.4.469.
Abstract
The naturally occurring virus papillomas of western cottontail rabbits become malignant occasionally. The cancers derive from the papilloma cells, that is to say from elements already rendered neoplastic by the virus and still infected therewith. Papillomas produced with the virus in jack rabbits and snowshoe rabbits become cancerous in the same way but much more frequently, as is the case in domestic rabbits also. To all three species the virus is foreign. The character of the cancers of the wild rabbits is described and the relation of the virus to them discussed on the basis of experimental findings. The facts support the view that the cancers result from virus variation, this in many instances being but slight.
摘要
自然界中的西部棉尾兔乳头瘤病毒偶尔会变得恶性。这些癌症来源于乳头瘤细胞，也就是说，来源于已经被病毒转化并仍然受到感染的细胞。用病毒在野兔和雪鞋兔中产生的乳头瘤也以同样的方式癌变，但更为频繁，家兔也是如此。这三种病毒对所有三种兔子来说都是外来的。根据实验结果，描述了野生兔子的癌症特征，并讨论了病毒与之的关系。这些事实支持了这样一种观点，即癌症是由病毒变异引起的，在许多情况下，这种变异只是轻微的。
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