关于血色素沉着症。
ON HEMOCHROMOGEN.
机构信息
Biophysical Laboratories of the Cancer Commission, Harvard University, Boston.
出版信息
J Gen Physiol. 1928 Nov 20;12(2):273-88. doi: 10.1085/jgp.12.2.273.
Abstract
- Every hemochromogen consists of the iron pyrrol complex, reduced heme, combined with some nitrogenous substance. 2. In every hemochromogen there is the equilibrium: Hemochromogen right arrow over left arrow Reduced heme + Nitrogenous substance. 3. Cyanide can form two distinct compounds with reduced heme, one of which is the typical hemochromogen, cyan-hemochromogen. 4. Reduced heme in alkaline solution has a great affinity for cyanide. 5. Cyan-hemochromogen probably contains one cyanide group per heme. 6. The hemochromogen prepared from hemoglobin is a compound of denatured globin and reduced heme. 7. The individual molecule of denatured globin, of hypothetical molecular weight 16,700, can convert at least 10 molecules of reduced heme into hemochromogen. 8. The hemochromogen-forming capacity of globin is, under given conditions, greater than that of edestin, which in turn, is greater than that of zein.
摘要
每个含铁血黄素原都由铁吡咯复合物、还原血红素与某种含氮物质组成。
在每个含铁血黄素原中都存在如下平衡：含铁血黄素原 ⇋ 还原血红素+含氮物质。
氰化物可以与还原血红素形成两种不同的化合物，其中之一就是典型的含铁血黄素原，氰-含铁血黄素原。
碱性溶液中的还原血红素有与氰化物强烈结合的倾向。
氰-含铁血黄素原可能每个血红素分子中都含有一个氰基。
从血红蛋白中制备的含铁血黄素原是变性球蛋白和还原血红素的化合物。
变性球蛋白的单个分子（假设分子量为 16700），至少可以将 10 个还原血红素分子转化为含铁血黄素原。
在给定条件下，球蛋白的形成含铁血黄素原的能力大于豆球蛋白，而豆球蛋白又大于玉米醇溶蛋白。
相似文献
1
ON HEMOCHROMOGEN.
J Gen Physiol. 1928 Nov 20;12(2):273-88. doi: 10.1085/jgp.12.2.273.
2
ON PYRIDINE HEMOCHROMOGEN.
J Gen Physiol. 1929 Mar 20;12(4):581-6. doi: 10.1085/jgp.12.4.581.
3
THE REACTIONS OF CYANIDE WITH GLOBIN HEMOCHROMOGEN.
J Gen Physiol. 1930 Sep 20;14(1):43-54. doi: 10.1085/jgp.14.1.43.
4
Tolerance to denatured globin hemochromogen. An experimental study.
Ann Surg. 1967 Dec;166(6):919-29. doi: 10.1097/00000658-196712000-00007.
5
PORPHYRIN COMPOUNDS DERIVED FROM BACTERIA.
J Gen Physiol. 1932 Jul 20;15(6):629-39. doi: 10.1085/jgp.15.6.629.
6
Effect of pH on the stability and molecular structure of nitrosyl hemochromogen.
Food Chem. 2016 Apr 1;196:503-8. doi: 10.1016/j.foodchem.2015.09.067. Epub 2015 Sep 25.
7
Pulmonary hemodynamic alterations following injections of denatured globin hemochromogen. An experimental study.
Bull Soc Int Chir. 1973 Mar-Apr;32(2):215-22.
8
Hemoglobin stability: observations on the denaturation of normal and abnormal hemoglobins by oxidant dyes, heat, and alkali.
J Clin Invest. 1970 Dec;49(12):2369-76. doi: 10.1172/JCI106456.
9
Rapid and sensitive quantitation of heme in hemoglobinized cells.
Biotechniques. 2016 Aug 1;61(2):83-91. doi: 10.2144/000114444. eCollection 2016.
10
The determination of hemoglobin as pyridine hemochromogen.
J Lab Clin Med. 1948 Dec;33(12):1638.
引用本文的文献
1
Quantification of Active Apohemoglobin Heme-Binding Sites via Dicyanohemin Incorporation.
Biochemistry. 2017 Oct 10;56(40):5245-5259. doi: 10.1021/acs.biochem.7b00683. Epub 2017 Sep 20.
2
Pyridine Hemochromagen Assay for Determining the Concentration of Heme in Purified Protein Solutions.
Bio Protoc. 2015;5(18). doi: 10.21769/bioprotoc.1594. Epub 2015 Sep 20.
3
Comparison of cyanide and carbon monoxide as ligands in iron(II) porphyrinates.
Angew Chem Int Ed Engl. 2009;48(27):5010-3. doi: 10.1002/anie.200901434.
本文引用的文献
1
ON SOME GENERAL PROPERTIES OF PROTEINS.
J Gen Physiol. 1925 Nov 20;9(2):169-79. doi: 10.1085/jgp.9.2.169.
2
On haemochromogen and the relation of protein to the properties of the haemoglobin molecule.
J Physiol. 1925 May 21;60(1-2):50-68. doi: 10.1113/jphysiol.1925.sp002220.
3
A spectroscopic method of estimating carbon monoxide.
J Physiol. 1912 Mar 29;44(1-2):1-21. doi: 10.1113/jphysiol.1912.sp001496.
4
The Reduction of Haematin and Methaemoglobin.
Biochem J. 1927;21(3):625-31. doi: 10.1042/bj0210625.
Zotero 插件