龙舌兰（jarilla）蛋白与革兰氏阴性菌蛋白的交叉反应。
Cross-reaction between proteins of Larrea divaricata Cav. (jarilla) and proteins of Gram-negative bacteria.
机构信息
Microbiology Unit, Department of Biochemistry and Biological Sciences, Faculty of Chemistry and Biochemistry and Pharmacy, National University of San Luis, San Luis, Argentina.
出版信息
Immunopharmacol Immunotoxicol. 2009;31(4):654-60. doi: 10.3109/08923970902971101.
Larrea divaricata is an abundant plant of northwest of Argentina used to treat different pathologies. We aimed to characterize the immunogenicity of proteins from a partially purified crude aqueous extract (JPCE) of jarilla. We evaluated the cross reaction between JPCE and whole cell-bacterial proteins (W-CBP) of Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, and Klebsiella pneumoniae using a mouse anti-JPCE serum. Protein profiles of JPCE and W-CBP were analyzed. For JPCE, 18 bands were observed in a 20-176 kDa range. Levels of IgG against JPCE and W-CBP were determined. Bacterial proteins showed a strong reaction with the anti-JPCE serum. Plant proteins could be used as immune stimulants.
拉雷亚分裂是阿根廷西北部一种丰富的植物，用于治疗不同的疾病。我们的目的是对一种部分纯化的粗水提物（JPCE）中的蛋白质的免疫原性进行表征。我们使用抗 JPCE 血清评估了 JPCE 与大肠杆菌、铜绿假单胞菌、普通变形杆菌和肺炎克雷伯菌的全细胞细菌蛋白（W-CBP）之间的交叉反应。分析了 JPCE 和 W-CBP 的蛋白图谱。对于 JPCE，在 20-176 kDa 范围内观察到 18 条带。测定了针对 JPCE 和 W-CBP 的 IgG 水平。细菌蛋白与抗 JPCE 血清有强烈反应。植物蛋白可用作免疫刺激剂。
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