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[痛觉机制]

[Mechanism of pain sensation].

作者信息

Gyulaházi Judit

机构信息

Debreceni Egyetem, Altalános Orvostudományi Kar, Budapest.

出版信息

Orv Hetil. 2009 Nov 15;150(46):2093-100. doi: 10.1556/OH.2009.28715.

Abstract

Pain, as subjective content of consciousness, is an essential attention-calling sign that helps to survive. Pain relieve is obligatory for every physician, thus, its individual appearance can make the analgesia difficult to carry out. The improving neuroimaging techniques allow understanding the development of pain sensation. Through the 24 articles on the PubMed found with keywords 'pain' and 'neuroimaging', we review here the parts of the pain neuron matrix, their tasks and the assumed mechanism of the acute pain sensation. The mechanism of the individual pain sensation is illustrated by the view of the modular function of the medial part of the pain matrix. Experimental results of empathic pain suggest that pain sensation may occur without real damage of the tissues, as well. The pain network plays main role in chronic pain.

摘要

疼痛作为意识的主观内容,是一种有助于生存的重要警示信号。缓解疼痛是每位医生的职责所在,然而,疼痛的个体差异可能会使镇痛变得困难。不断改进的神经成像技术有助于理解痛觉的产生过程。通过在PubMed上搜索关键词“疼痛”和“神经成像”找到的24篇文章,我们在此回顾疼痛神经元矩阵的组成部分、它们的任务以及急性痛觉的假定机制。从疼痛矩阵内侧部分的模块化功能角度阐述了个体痛觉的机制。共情疼痛的实验结果表明,即使组织没有实际损伤也可能产生痛觉。疼痛网络在慢性疼痛中起主要作用。

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