[丙型肝炎病毒对白细胞的嗜性——通过测序分析病毒E1和E2包膜糖蛋白基因的重要性]

[Tropism of hepatitis C virus for leukocytes-- importance of the analysis of viral E1 and E2 envelope glycoprotein genes by sequencing].

作者信息

Moenne-Loccoz R, Razafinjatovo C, Habersetzer F, Ananna A, Doffoel M, Wolf P, Gut J-P, Baumert T, Stoll-Keller F, Schvoerer E

机构信息

Unité Inserm 748, 3, rue Koeberlé, 67000 Strasbourg, France.

出版信息

Pathol Biol (Paris). 2010 Apr;58(2):170-4. doi: 10.1016/j.patbio.2009.06.010. Epub 2009 Nov 4.

DOI:10.1016/j.patbio.2009.06.010

PMID:19892492

Abstract

The ability of hepatitis C virus (HCV) to infect leukocytes could favour HCV pathogenesis. Although viral infection of these immunocompetent cells is poorly (or not) productive, the impact on their immunomodulatory functions could be important. Viral envelope glycoproteins E1 and E2, because of their crucial role in the recognition of viral receptors on permissive cells, could contribute to viral leukocytic tropism and, as a consequence, to the pathophysiology of HCV chronic infection.

摘要

丙型肝炎病毒（HCV）感染白细胞的能力可能有利于HCV发病机制。尽管这些具有免疫活性的细胞的病毒感染效率很低（或无感染性），但其对免疫调节功能的影响可能很重要。病毒包膜糖蛋白E1和E2因其在识别允许性细胞上的病毒受体方面的关键作用，可能有助于病毒的白细胞嗜性，进而影响HCV慢性感染的病理生理学。