大肠杆菌小亚基核糖体RNA 900四环中C899残基的功能研究
Functional study of the residue C899 in the 900 tetraloop of Escherichia coli small subunit ribosomal RNA.
作者信息
Ha Hye-Jeong, Song Woo-Seok, Kim Hong-Man, Son Ho-Sun, Lee Kangseok
机构信息
Department of Life Science, Chung-Ang University, Seoul, Republic of Korea.
出版信息
Biosci Biotechnol Biochem. 2009 Nov;73(11):2544-6. doi: 10.1271/bbb.90460. Epub 2009 Nov 7.
PMID:19897894
Abstract
A mutant ribosome bearing C899G in the 900 tetraloop of Escherichia coli 16S rRNA, one implicated in a conformational switch in the dynamic movements of the ribosome, showed defects in subunit association and 30S initiation complex formation. Our results explain the basis of the loss of protein synthesis ability caused by a perturbation of the 900 tetraloop.
摘要
在大肠杆菌16S rRNA的900四环中携带C899G的突变核糖体，与核糖体动态运动中的构象转换有关，在亚基结合和30S起始复合物形成方面存在缺陷。我们的结果解释了由900四环扰动导致蛋白质合成能力丧失的基础。
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