吡唑并[3,4-d]嘧啶并菲烷：一类新型环芳烷的便捷合成及首例代表物的 X 射线结构
Pyrazolo[3,4-d]pyrimidinophanes: convenient synthesis of a new class of cyclophane and X-ray structure of the first representative.
机构信息
Medicinal and Process Chemistry Division and Molecular and Structural Biology Division, Central Drug Research Institute, CSIR, Lucknow 226001, India.
出版信息
Org Lett. 2009 Nov 19;11(22):5290-3. doi: 10.1021/ol902264t.
PMID:19905030
Abstract
A convenient synthesis of a new class of novel pyrazolo[3,4-d]pyrimidinophanes (four products, 41%), a new class of cyclophane, and X-ray structure of the first dissymmetrical [3.4]pyrazolo[3,4-d]pyrimidinophane (22%) are reported for the first time. The conformation of major syn product 6b is stabilized by weak pi-pi and O...Ar interactions.
摘要
首次报道了一类新型吡唑并[3,4-d]嘧啶并菲烷（四个产物，41%）、一类新型环芳烷以及首例不对称[3.4]吡唑并[3,4-d]嘧啶并菲烷（22%）的简便合成方法。主要顺式产物 6b 的构象由弱的π-π和 O...Ar 相互作用稳定。
相似文献
1
Pyrazolo[3,4-d]pyrimidinophanes: convenient synthesis of a new class of cyclophane and X-ray structure of the first representative.吡唑并[3,4-d]嘧啶并菲烷：一类新型环芳烷的便捷合成及首例代表物的 X 射线结构
Org Lett. 2009 Nov 19;11(22):5290-3. doi: 10.1021/ol902264t.
2
Ultrasound assisted one-pot, three-components synthesis of pyrimido[1,2-a]benzimidazoles and pyrazolo[3,4-b]pyridines: A new access via phenylsulfone synthon.超声辅助一锅法、三组分合成嘧啶并[1,2-a]苯并咪唑和吡唑并[3,4-b]吡啶：通过苯砜合成子的新途径。
Ultrason Sonochem. 2012 Jan;19(1):49-55. doi: 10.1016/j.ultsonch.2011.05.003. Epub 2011 May 8.
3
Non-hinge-binding pyrazolo[1,5-a]pyrimidines as potent B-Raf kinase inhibitors.非铰链结合的吡唑并[1,5-a]嘧啶作为强效 B-Raf 激酶抑制剂。
Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23. doi: 10.1016/j.bmcl.2009.10.049. Epub 2009 Oct 26.
4
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.2-氨基哒嗪并[1,5-a]嘧啶作为强效和选择性 JAK2 抑制剂。
Bioorg Med Chem Lett. 2009 Dec 1;19(23):6529-33. doi: 10.1016/j.bmcl.2009.10.053. Epub 2009 Oct 24.
5
Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.含有吡唑并[3,4-d]嘧啶环系的新型高效腺苷脱氨酶抑制剂。合成、构效关系及分子模拟研究。
J Med Chem. 2005 Aug 11;48(16):5162-74. doi: 10.1021/jm050136d.
6
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.吡唑并嘧啶类：一种用于高效选择性p38α抑制剂的新型杂环骨架。
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2652-7. doi: 10.1016/j.bmcl.2008.03.019. Epub 2008 Mar 10.
7
Anhydrous versus hydrated N4-substituted 1H-pyrazolo[3,4-d]pyrimidine-4,6-diamines: hydrogen bonding in two and three dimensions.无水与水合的N4-取代的1H-吡唑并[3,4-d]嘧啶-4,6-二胺：二维和三维中的氢键作用
Acta Crystallogr B. 2008 Oct;64(Pt 5):610-22. doi: 10.1107/S0108768108019903. Epub 2008 Sep 15.
8
3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.3-氨基吡唑并[3,4-d]嘧啶作为 p38α 激酶抑制剂的设计与开发：从高选择性先导化合物出发。
Bioorg Med Chem Lett. 2011 Jun 1;21(11):3452-6. doi: 10.1016/j.bmcl.2011.03.098. Epub 2011 Apr 1.
9
Design and synthesis of 3-(2-pyridyl)pyrazolo[1,5-a]pyrimidines as potent CRF1 receptor antagonists.作为强效促肾上腺皮质激素释放因子1（CRF1）受体拮抗剂的3-（2-吡啶基）吡唑并[1,5-a]嘧啶的设计与合成
Bioorg Med Chem Lett. 2004 Aug 2;14(15):3943-7. doi: 10.1016/j.bmcl.2004.05.056.
10
Resourceful synthesis of pyrazolo[1,5-a]pyrimidines under ultrasound irradiation.超声辐射下的吡唑并[1,5-a]嘧啶的灵活合成。
Ultrason Sonochem. 2013 Sep;20(5):1139-43. doi: 10.1016/j.ultsonch.2013.02.006. Epub 2013 Mar 6.
Zotero 插件