类固醇生成因子1（SF-1）和类固醇生成急性调节蛋白（StAR）在子宫内膜异位症中的表达与子宫内膜异位症的严重程度相关。
Expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis is associated with endometriosis severity.
作者信息
Tian Yongjie, Kong B, Zhu W, Su S, Kan Y
机构信息
Department of Obstetrics and Gynaecology, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China.
出版信息
J Int Med Res. 2009 Sep-Oct;37(5):1389-95. doi: 10.1177/147323000903700513.
This study was designed to investigate the levels of expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis, and to explore the association between these two factors and the menstrual cycle and the severity of endometriosis. Levels of SF-1 and StAR protein were evaluated using immunohistochemistry in 38 cases of endometriosis with ectopic endometria and in 25 normal endometria (controls). The SF-1 and StAR protein levels were significantly higher in ectopic endometria than in normal endometria. There was a significant correlation between the level of SF-1 and StAR in ectopic endometriotic tissues. It is concluded that protein levels of SF-1 and StAR are upregulated in ectopic endometria and are significantly correlated with the severity of endometriosis.
本研究旨在调查子宫内膜异位症中类固醇生成因子1（SF-1）和类固醇生成急性调节蛋白（StAR）的表达水平，并探讨这两个因子与月经周期及子宫内膜异位症严重程度之间的关联。采用免疫组织化学方法评估了38例伴有异位内膜的子宫内膜异位症患者以及25例正常子宫内膜（对照组）中SF-1和StAR蛋白的水平。异位内膜中SF-1和StAR蛋白水平显著高于正常内膜。异位子宫内膜组织中SF-1和StAR水平之间存在显著相关性。得出结论：异位内膜中SF-1和StAR的蛋白水平上调，且与子宫内膜异位症的严重程度显著相关。
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