Toll样受体9：天冬氨酸内肽酶发挥调控作用。

Toll-like receptor 9: AEP takes control.

作者信息

van Endert Peter

机构信息

Inserm, U580, Paris 75015, France.

出版信息

Immunity. 2009 Nov 20;31(5):696-8. doi: 10.1016/j.immuni.2009.10.004.

DOI:10.1016/j.immuni.2009.10.004

PMID:19932067

Abstract

Toll-like receptor 9 (TLR9) requires proteolytic maturation to acquire signaling capacity; however, the involved protease(s) is unclear. In this issue of Immunity, Sepulveda et al. (2009) demonstrate that in dendritic cells, asparaginyl endopeptidase is a key protease that controls TLR9 maturation.

摘要

Toll样受体9（TLR9）需要通过蛋白水解成熟来获得信号传导能力；然而，所涉及的蛋白酶尚不清楚。在本期《免疫》杂志中，塞普尔韦达等人（2009年）证明，在树突状细胞中，天冬酰胺内肽酶是控制TLR9成熟的关键蛋白酶。