Department of Medicine, Lymphoma Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Clin Cancer Res. 2009 Dec 1;15(23):7114-5. doi: 10.1158/1078-0432.CCR-09-2233. Epub 2009 Nov 24.
Chromosomal integrity is vital to the life span of the dividing cell. Telomeres are tandem sequences at chromosome ends that provide protection for the genetic coding material. Erosion of those ends leads to cell death. Does stabilization promote cancer?
染色体完整性对分裂细胞的寿命至关重要。端粒是染色体末端的串联序列,可为遗传编码物质提供保护。这些末端的侵蚀会导致细胞死亡。稳定端粒会促进癌症的发生吗?