纳米颗粒载体靶向递药治疗炎症性疾病。
Targeted drug-delivery approaches by nanoparticulate carriers in the therapy of inflammatory diseases.
机构信息
Laboratory of Pharmaceutical Technology and Biopharmaceutics, University of Bonn, Bonn, Germany.
出版信息
J R Soc Interface. 2010 Feb 6;7 Suppl 1(Suppl 1):S55-66. doi: 10.1098/rsif.2009.0285.focus. Epub 2009 Nov 25.
Abstract
Limitations in therapy induced by adverse effects due to unselective drug availability and therefore the use of potentially too high doses are a common problem. One prominent example for this dilemma are inflammatory diseases. Colloidal carriers allow one to improve delivery of drugs to the site of action and appear promising to overcome this general therapeutic drawback. Specific uptake of nanoparticles by immune-related cells in inflamed barriers offers selective drug targeting to the inflamed tissue. Here we focus on nanocarrier-based drug delivery strategies for the treatment of common inflammatory disorders like rheumatoid arthritis, multiple sclerosis, uveitis or inflammatory bowel disease.
摘要
由于药物非选择性可用性导致的不良反应限制了治疗效果，因此需要使用潜在过高剂量的药物，这是一个常见的问题。这种困境的一个突出例子是炎症性疾病。胶体载体可以改善药物在作用部位的传递，似乎有希望克服这一普遍的治疗缺陷。纳米颗粒被炎症屏障中与免疫相关的细胞特异性摄取，为炎症组织提供了选择性的药物靶向。在这里，我们专注于基于纳米载体的药物传递策略，用于治疗常见的炎症性疾病，如类风湿性关节炎、多发性硬化症、虹膜炎或炎症性肠病。
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