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病灶内注射皮质类固醇治疗中央巨细胞肉芽肿:儿童的一种替代治疗方法

Intralesional corticosteroid injection for central giant cell granuloma: an alternative treatment for children.

作者信息

Wendt Flavia Prietsh, Torriani Marcos Antônio, Gomes Ana Paula Neutzling, de Araujo Lenita Maria Aver, Torriani Dione Dias

机构信息

Dentistry School of Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.

出版信息

J Dent Child (Chic). 2009 Sep-Dec;76(3):229-32.

Abstract

The purpose of the present article was to report a case of central giant cell granuloma (CGCG) associated with intralesional corticosteroid injections. Although benign, the CGCG may be locally aggressive, causing extensive bone destruction, tooth displacement, and root resorption. The common therapy is surgery, which may result in important facial deformity and loss of teeth or dental germs. In this article, an 8-year-old girl who presented with maxillary CGCG was treated with a solution of equal parts of triamcinolone actinide (10 mg/ml) and 0.5% bupivacaine injected into the lesion for a period of 11 weeks. The osseous neoformation was gradual. After 6-years follow-up, clinical and radiographic success of treatment were observed. Based on our results and the literature available, the administration of intralesional corticosteroid injections is an alternative in CGCG treatment, especially in children.

摘要

本文的目的是报告一例与病灶内注射皮质类固醇相关的中央巨细胞肉芽肿(CGCG)病例。尽管CGCG是良性的,但可能具有局部侵袭性,导致广泛的骨质破坏、牙齿移位和牙根吸收。常见的治疗方法是手术,这可能会导致严重的面部畸形以及牙齿或牙胚缺失。在本文中,一名患有上颌骨CGCG的8岁女孩接受了将曲安奈德(10 mg/ml)和0.5%布比卡因等量混合的溶液注射到病灶内的治疗,为期11周。骨质新形成是渐进性的。经过6年的随访,观察到治疗在临床和影像学上均取得成功。基于我们的结果和现有文献,病灶内注射皮质类固醇是CGCG治疗的一种替代方法,尤其是在儿童中。

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