雄激素受体基因（CAG）n多态性与男性不育的关联：一项荟萃分析

[Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis].

作者信息

Li Ya, Wang Lun-an, Wu Tai-xiang

机构信息

Department of Biochemistry and Molecular Biology, Chengdu Medical College, Chengdu, Sichuan 610081, China.

出版信息

Zhonghua Nan Ke Xue. 2009 Sep;15(9):809-13.

PMID:19947564

Abstract

OBJECTIVE

To assess the association of male infertility with CAG repeat polymorphism of the androgen receptor (AR) gene by meta-analysis.

METHODS

We identified the case-control studies on the relationship of male infertility with CAG repeats of the AR gene by searching Medline/PubMed and CBM databases, and conducted meta-analysis on the data obtained with the RevMan 4.2 software.

RESULTS

Thirty-two eligible articles were selected in this study, including 3,153 idiopathic infertile men and 2,314 controls. The combined data statistics showed that all the infertile men had a significantly higher mean of CAG repeats than the controls (SMD = 0.27, 95% CI: 0.17-0.37, P < 0.01). The specific SMD between the infertile patients and controls was 0.29, 95% CI: 0.08-0.50 for the azoospermic men, 0.27, 95% CI: 0.13-0.41 for the moderate oligozoospermic men, and 0.18, 95% CI: 0.02-0.33 for the severe oligozoospermic cases. The results of sensitivity analyses were consistent with those mentioned above.

CONCLUSION

The increased length of CAG repeats in the AR gene may be correlated with the risk of the impairment of spermatogenesis.

摘要

目的

通过荟萃分析评估男性不育与雄激素受体（AR）基因CAG重复多态性之间的关联。

方法

通过检索Medline/PubMed和中国生物医学文献数据库（CBM），确定关于男性不育与AR基因CAG重复关系的病例对照研究，并使用RevMan 4.2软件对获得的数据进行荟萃分析。

结果

本研究共纳入32篇合格文章，包括3153例特发性不育男性和2314例对照。合并数据统计显示，所有不育男性的CAG重复平均次数显著高于对照组（标准化均数差[SMD]=0.27，95%置信区间[CI]：0.17 - 0.37，P<0.01）。不育患者与对照组之间的具体SMD为：无精子症男性为0.29，95%CI：0.08 - 0.50；中度少精子症男性为0.27，95%CI：0.13 - 0.41；重度少精子症病例为0.18，95%CI：0.02 - 0.33。敏感性分析结果与上述结果一致。