N-acetylcysteine, reactive oxygen species and beyond.
作者信息
Sun Shi-Yong
机构信息
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
出版信息
Cancer Biol Ther. 2010 Jan;9(2):109-10. doi: 10.4161/cbt.9.2.10583. Epub 2010 Jan 10.
Abstract
摘要
相似文献
1
N-acetylcysteine, reactive oxygen species and beyond.
Cancer Biol Ther. 2010 Jan;9(2):109-10. doi: 10.4161/cbt.9.2.10583. Epub 2010 Jan 10.
2
Downregulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhetinic acid derivatives in leukemia cells.
Cancer Biol Ther. 2010 Jan;9(2):96-108. doi: 10.4161/cbt.9.2.10287. Epub 2010 Jan 9.
3
ABT-737 increases tyrosine kinase inhibitor-induced apoptosis in chronic myeloid leukemia cells through XIAP downregulation and sensitizes CD34(+) CD38(-) population to imatinib.
Exp Hematol. 2012 May;40(5):367-78.e2. doi: 10.1016/j.exphem.2012.01.004. Epub 2012 Jan 10.
4
Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia.
Br J Haematol. 2013 Jan;160(2):188-98. doi: 10.1111/bjh.12108. Epub 2012 Nov 20.
5
Omacetaxine added to a standard acute myeloid leukaemia chemotherapy regimen reduces cellular FLIP levels, markedly increasing the incidence of eccrine hidradenitis.
Br J Haematol. 2021 Nov;195(3):e138-e141. doi: 10.1111/bjh.17715. Epub 2021 Sep 7.
6
Synthesis of methyl 2-cyano-3,12-dioxo-18β-olean-1,9(11)-dien-30-oate analogues to determine the active groups for inhibiting cell growth and inducing apoptosis in leukemia cells.
Org Biomol Chem. 2014 Sep 14;12(34):6706-16. doi: 10.1039/c4ob00703d.
7
Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L).
Cell Death Dis. 2014 Feb 20;5(2):e1063. doi: 10.1038/cddis.2014.35.
8
The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation.
Cancer Res. 2007 Oct 1;67(19):9490-500. doi: 10.1158/0008-5472.CAN-07-0598.
9
Plumbagin enhances TRAIL-induced apoptosis of human leukemic Kasumi‑1 cells through upregulation of TRAIL death receptor expression, activation of caspase-8 and inhibition of cFLIP.
Oncol Rep. 2017 Jun;37(6):3423-3432. doi: 10.3892/or.2017.5627. Epub 2017 May 4.
10
The experimental and clinical study on the effect of curcumin on cell cycle proteins and regulating proteins of apoptosis in acute myelogenous leukemia.
J Huazhong Univ Sci Technolog Med Sci. 2002;22(4):295-8. doi: 10.1007/BF02896768.
引用本文的文献
1
GSR Deficiency Exacerbates Oxidative Stress and Promotes Pulmonary Fibrosis.
Biomolecules. 2025 Jul 20;15(7):1050. doi: 10.3390/biom15071050.
2
Potassium Iodide Induces Apoptosis in Salivary Gland Cancer Cells.
Int J Mol Sci. 2025 May 28;26(11):5199. doi: 10.3390/ijms26115199.
3
Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospects.
Biogerontology. 2025 May 26;26(3):118. doi: 10.1007/s10522-025-10256-5.
4
Germline Single-Nucleotide Polymorphism Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia.
Biomedicines. 2025 Jan 5;13(1):107. doi: 10.3390/biomedicines13010107.
5
Antitumor activity of bimetallic silver/gold nanoparticles against MCF-7 breast cancer cells.
RSC Adv. 2024 Dec 10;14(53):39102-39111. doi: 10.1039/d4ra06227b.
6
TRPM7 contributes to pyroptosis and its involvement in status epilepticus.
J Neuroinflammation. 2024 Dec 1;21(1):315. doi: 10.1186/s12974-024-03292-4.
7
Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK-inhibitor-induced tolerant persister cells in ALK-fusion-positive lung cancer.
Mol Oncol. 2025 Feb;19(2):519-539. doi: 10.1002/1878-0261.13746. Epub 2024 Oct 6.
8
Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein.
Elife. 2024 Oct 2;13:RP98665. doi: 10.7554/eLife.98665.
9
Mitochondrial Dysfunction in Systemic Lupus Erythematosus: Insights and Therapeutic Potential.
Diseases. 2024 Sep 23;12(9):226. doi: 10.3390/diseases12090226.
10
Dielectrophoretic characterization of peroxidized retinal pigment epithelial cells as a model of age-related macular degeneration.
BMC Ophthalmol. 2024 Aug 13;24(1):340. doi: 10.1186/s12886-024-03617-0.
本文引用的文献
1
Downregulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhetinic acid derivatives in leukemia cells.
Cancer Biol Ther. 2010 Jan;9(2):96-108. doi: 10.4161/cbt.9.2.10287. Epub 2010 Jan 9.
2
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors.
Blood. 2009 Jun 4;113(23):5927-37. doi: 10.1182/blood-2008-07-171389. Epub 2009 Feb 3.
3
Glutathione and apoptosis.
Free Radic Res. 2008 Aug;42(8):689-706. doi: 10.1080/10715760802317663.
4
Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3.
Cancer Res. 2008 Apr 15;68(8):2920-6. doi: 10.1158/0008-5472.CAN-07-3036.
5
Oxidative stress and apoptosis: impact on cancer therapy.
J Pharm Sci. 2007 Sep;96(9):2181-96. doi: 10.1002/jps.20874.
6
Mitochondria, oxidative stress and cell death.
Apoptosis. 2007 May;12(5):913-22. doi: 10.1007/s10495-007-0756-2.
7
Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer.
Nat Rev Cancer. 2007 May;7(5):357-69. doi: 10.1038/nrc2129. Epub 2007 Apr 19.
8
The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole blocks nuclear factor-kappaB activation through direct inhibition of IkappaB kinase beta.
Mol Cancer Ther. 2006 Dec;5(12):3232-9. doi: 10.1158/1535-7163.MCT-06-0444. Epub 2006 Dec 5.
9
Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
J Biol Chem. 2006 Nov 24;281(47):35764-9. doi: 10.1074/jbc.M607160200. Epub 2006 Sep 24.
10
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me).
Cancer Biol Ther. 2006 May;5(5):492-7. doi: 10.4161/cbt.5.5.2565. Epub 2006 May 2.
Zotero 插件