糠酸莫米松鼻喷雾剂治疗变应性鼻炎
[Treatment of allergic rhinitis with nasal mometasone furoate].
作者信息
Zhang Luo, Xu Geng, Wang Xiang-dong, Liu Shi-xi, Li Yuan, Wang Shen-qing, Yang Bei-bei, Zheng Chun-quan, Wang Cheng-shuo, Dong Pin, Lin Zi-ping, Zhang Hua, Han De-min
机构信息
Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Beijing, 100730 China.
出版信息
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jun;44(6):455-9.
OBJECTIVE
To evaluate the effects of nasal mometasone furoate on moderate to severe allergic rhinitis.
METHODS
Patients with moderate to severe allergic rhinitis were enrolled and received mometasone furoate nasal spray 200 microg once daily for four weeks. Four hundreds and sixty-three patients completed the study. We weekly interviewed the patients to evaluate the symptoms, and the affection of disease on night sleep and daily life. Mini Rhinoconjunctivitis Quality of Life Questionnaire (Mini-RQLQ) and Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire (NRQLQ) were used to evaluate the quality of life.
RESULTS
The individual and total symptomatic scores of week 1, week 2 and week 4 decreased compared with baseline. The scores of Mini-RQLQ and NRQLQ of week 1, week 2 and week 4 decreased compared with baseline too. The scores of the next visit were significantly lower than those of the previous visit (P < 0.01).
CONCLUSIONS
A four-week administration of mometasone furoate nasal spray can effectively treat allergic rhinitis.
目的
评估糠酸莫米松鼻喷雾剂对中重度变应性鼻炎的疗效。
方法
招募中重度变应性鼻炎患者，给予糠酸莫米松鼻喷雾剂200微克，每日1次，共4周。463例患者完成了研究。我们每周对患者进行访谈以评估症状，以及疾病对夜间睡眠和日常生活的影响。使用迷你鼻结膜炎生活质量问卷（Mini-RQLQ）和夜间鼻结膜炎生活质量问卷（NRQLQ）评估生活质量。
结果
第1周、第2周和第4周的个体症状评分和总症状评分与基线相比均降低。第1周、第2周和第4周的Mini-RQLQ和NRQLQ评分与基线相比也降低。下次访视的评分显著低于上一次访视（P<0.01）。
结论
糠酸莫米松鼻喷雾剂给药4周可有效治疗变应性鼻炎。
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