B 族维生素在心血管风险中的争议性作用：最新研究进展。

The controversial role of B-vitamins in cardiovascular risk: An update.

机构信息

First Propedeutic Department of Internal Medicine, AHEPA Hospital, Aristotle University, S. Kiriakidi 1, 54636, Thessaloniki, Greece.

出版信息

Arch Cardiovasc Dis. 2009 Dec;102(12):847-54. doi: 10.1016/j.acvd.2009.07.002.

DOI:10.1016/j.acvd.2009.07.002

PMID:19963194

Abstract

Cardiovascular disease is the leading cause of death in Western countries. Since 1969, homocysteine has been implicated in the atherosclerotic process, and numerous observational studies have suggested that hyperhomocysteinaemia should be considered as an independent cardiovascular risk factor. B-vitamins, particularly folic acid, reduce homocysteine levels effectively; it was suggested, therefore, that supplementation with these vitamins might decrease cardiovascular risk and reduce the morbidity and mortality associated with stroke, coronary heart disease and peripheral artery disease. However, the results of clinical trials conducted to investigate this issue have been inconsistent. This review discusses the findings of these trials and provides an updated overview on the 'homocysteine hypothesis'.

摘要

心血管疾病是西方国家的主要死亡原因。自 1969 年以来，同型半胱氨酸已被牵涉到动脉粥样硬化过程中，许多观察性研究表明，高同型半胱氨酸血症应被视为独立的心血管危险因素。B 族维生素，特别是叶酸，能有效地降低同型半胱氨酸水平；因此，有人认为补充这些维生素可能会降低心血管风险，并降低与中风、冠心病和外周动脉疾病相关的发病率和死亡率。然而，为研究这一问题而进行的临床试验的结果并不一致。本综述讨论了这些试验的结果，并就“同型半胱氨酸假说”提供了最新的概述。