Presti B, Weidner N
Department of Pathology, St. Mary Corwin Hospital, Pueblo, Colorado.
Am J Clin Pathol. 1991 Mar;95(3):330-4. doi: 10.1093/ajcp/95.3.330.
Granulomatous prostatitis and poorly differentiated prostate carcinoma can mimic each other both clinically and histologically. To develop criteria useful in resolving problem cases, the authors compared the reactivities of these conditions (nine cases of granulomatous prostatitis and six cases of poorly differentiated carcinoma) with a panel of antibodies to cytokeratin (AE1/3), prostate-specific antigen (PSA), prostatic acid phosphatase (PAP), lysozyme, antimacrophage M, and leukocyte common antigen (LCA). In granulomatous prostatitis, histiocytes were not immunoreactive for PAP, PSA, or cytokeratin; however, histiocytes reacted to lysozyme in nine of nine cases, antimacrophage M in seven of nine cases, and LCA in one of nine cases. Tumor cells from all six carcinoma cases reacted with PAP, PSA, and cytokeratin; all failed to react with lysozyme, LCA, and antimacrophage M. The authors conclude that granulomatous prostatitis and poorly differentiated carcinoma can be reliably distinguished with immunohistochemical methods.
肉芽肿性前列腺炎和低分化前列腺癌在临床和组织学上均可相互模仿。为制定有助于解决疑难病例的标准，作者将这些病例（9例肉芽肿性前列腺炎和6例低分化癌）与一组针对细胞角蛋白（AE1/3）、前列腺特异性抗原（PSA）、前列腺酸性磷酸酶（PAP）、溶菌酶、抗巨噬细胞M和白细胞共同抗原（LCA）的抗体的反应性进行了比较。在肉芽肿性前列腺炎中，组织细胞对PAP、PSA或细胞角蛋白无免疫反应；然而，9例中有9例组织细胞对溶菌酶有反应，9例中有7例对抗巨噬细胞M有反应，9例中有1例对LCA有反应。所有6例癌病例的肿瘤细胞均与PAP、PSA和细胞角蛋白发生反应；所有病例均未与溶菌酶、LCA和抗巨噬细胞M发生反应。作者得出结论，肉芽肿性前列腺炎和低分化癌可用免疫组织化学方法可靠地区分。
