载药聚合物纳米颗粒的制备及其对脂质过氧化抗氧化活性的评价。

Preparation of drug-loaded polymeric nanoparticles and evaluation of the antioxidant activity against lipid peroxidation.

作者信息

Pohlmann Adriana R, Schaffazick Scheila Rezende, Creczynski-Pasa Tânia B, Guterres Sílvia S

机构信息

Instituto de Química da Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.

出版信息

Methods Mol Biol. 2010;610:109-21. doi: 10.1007/978-1-60327-029-8_7.

DOI:10.1007/978-1-60327-029-8_7

PMID:20013175

Abstract

Antioxidants have been found to be effective as prophylatic and therapeutic agents for different diseases such as diabetes, cancer, and neurodegenerative disorders. However, antioxidant substances can present poor solubility in water, inefficient permeability, gastrointestinal degradation, first-pass effect, and/or instability during storage. These drawbacks can be potentially circumvented by encapsulating the susceptible antioxidants. Polymeric nanoparticles (nanocapsules or nanospheres) have been used to improve the drug efficacy and release. Our group has shown that the in vitro antioxidant effect of melatonin against lipid peroxidation in microsomes and liposomes can be improved by encapsulation of the antioxidant drug in polymeric nanoparticles.

摘要

抗氧化剂已被发现可作为预防和治疗不同疾病（如糖尿病、癌症和神经退行性疾病）的有效药物。然而，抗氧化物质可能存在水溶性差、渗透性低、胃肠道降解、首过效应和/或储存期间不稳定等问题。通过封装易氧化的抗氧化剂，这些缺点可能会得到有效解决。聚合物纳米颗粒（纳米胶囊或纳米球）已被用于提高药物疗效和释放效果。我们的研究小组表明，通过将抗氧化药物封装在聚合物纳米颗粒中，褪黑素对微粒体和脂质体中脂质过氧化的体外抗氧化作用可以得到改善。