长期抗菌治疗预防复发性软组织感染。
Long-term antimicrobial therapy in the prevention of recurrent soft-tissue infections.
作者信息
Kremer M, Zuckerman R, Avraham Z, Raz R
机构信息
Department of Dermatology, Zvulum Outpatient Clinic, Kyriat Motzkin, Israel.
出版信息
J Infect. 1991 Jan;22(1):37-40. doi: 10.1016/0163-4453(91)90898-3.
Thirty-six patients who had suffered two or more episodes of erysipelas or cellulitis during the previous year were randomly divided into two equal groups; one group received erythromycin base 250 mg b.i.d. for 18 months, while the other group received no prophylaxis for a similar period. No patients in the treated group developed infection during the 18 months' follow-up but eight of the control group (50%) relapsed and required antibiotic treatment. Prolonged antimicrobial prophylaxis is effective and safe in preventing recurrent episodes of soft-tissue infections.
36名在前一年曾经历过两次或更多次丹毒或蜂窝织炎发作的患者被随机分为两组，每组人数相等；一组患者每日两次口服250毫克红霉素碱，持续18个月，而另一组在相同时间段内未接受预防性治疗。在18个月的随访期内，治疗组中没有患者发生感染，但对照组中有8名患者（50%）复发并需要抗生素治疗。长期抗菌预防在预防软组织感染复发方面是有效且安全的。
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