多巴胺部分激动剂对精神分裂症患者尼古丁依赖的影响。
The effect of dopamine partial agonists on the nicotine dependency in patients with schizophrenia.
作者信息
Kim Se Hee, Han Doug Hyun, Joo So Youn, Min Kyung Joon
机构信息
Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea.
出版信息
Hum Psychopharmacol. 2010 Mar;25(2):187-90. doi: 10.1002/hup.1089.
OBJECTIVE
We compared the effects of haloperidol and three atypical antipsychotics (risperidone, olanzapine, and aripiprazole) on nicotine dependence in schizophrenic patients.
METHODS
One hundred and thirty nine schizophrenic patients, who began using antipsychotic medication, were assessed for severity of nicotine dependence and for cigarette craving at baseline and following 8 weeks of treatment using the Fagerström Tolerance Questionnaire (FTQ) and a Likert-style, seven point, visual-analogue rating scale.
RESULTS
Nicotine dependence increased in the haloperidol group, but not in atypical antipsychotics groups. Patients treated with aripiprazole showed a reduction both in nicotine dependence and cigarette craving.
CONCLUSIONS
The effects of aripiprazole, a partial agonist of the dopamine D2 receptor, may reduce the severity of nicotine dependence in schizophrenic patients.
目的
我们比较了氟哌啶醇和三种非典型抗精神病药物（利培酮、奥氮平和阿立哌唑）对精神分裂症患者尼古丁依赖的影响。
方法
139名开始使用抗精神病药物治疗的精神分裂症患者，在基线时以及使用法格斯特罗姆耐受问卷（FTQ）和李克特式七点视觉模拟评分量表治疗8周后，评估其尼古丁依赖的严重程度和对香烟的渴望程度。
结果
氟哌啶醇组的尼古丁依赖增加，而非典型抗精神病药物组则没有。接受阿立哌唑治疗的患者在尼古丁依赖和对香烟的渴望方面均有所降低。
结论
多巴胺D2受体部分激动剂阿立哌唑的作用可能会降低精神分裂症患者尼古丁依赖的严重程度。
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